Proceedings: Toxic effect of N-methyl-N-nitrosourea on normal and transformed cells
نویسندگان
چکیده
منابع مشابه
The toxic effect of spermidine on normal and transformed cells.
The cytotoxic effect of spermidine was investigated on various tissue culture cell lines in the presence of calf serum. Cells incubated with cytotoxic concentrations remained rounded up while cells in control cultures always spread out on the surface of the Petri dish. The spermidine concentration tolerated depends on cell number, concentration of serum, the strain of cells used and the phase o...
متن کاملPreventive effect of Oenothera rosea on N-methyl-N-nitrosourea-(NMU) induced gastric cancer in rats
Background Currently, gastric cancer (GC) is considered a public health problem worldwide. Using medicinal plants for the prevention of chronic diseases such as cancer constitutes new alternatives in traditional medicine. Oenothera rosea (OR) could be an option, but it needs to be evaluated. Aim The main objective of this study was to evaluate the protective effect of OR extract on N-methyl-N...
متن کاملEffect of N-Methyl-N-Nitrosourea on Helicobacter-induced Gastric Carcinogenesis in C57BL/6 Mice
BACKGROUND The aim of this study was to investigate the effect of N-methyl-N-nitrosourea (MNU) treatment followed by chronic Helicobacter pylori SS1 and H. felis colonization on the stomachs of C57BL/6 mice. The role of MNU and Helicobacter species in gastric carcinogenesis was also elucidated. METHODS A total of 69 C57BL/6 mice at 4 weeks of age were divided into 6 groups according to MNU tr...
متن کاملEffect of N-methyl-N-nitrosourea on the protein-synthesizing system in mouse liver and hepatoma 22a cells.
SUMMARY A single injection of nitrosomethylurea (80 mg/kg body weight) to mice bearing hepatoma 22a led to an injury of the main components of the protein-synthesizing system (poly ribosomal complex and soluble factors of the cell sap) in liver and hepatoma cells. In liver cells of adult animals, the activity of the protein-synthesizing system returns to a normal level 5 to 15 hr after injectio...
متن کاملNon-phenotypic selection of N-methyl-N-nitrosourea-induced mutations in human cells.
The distribution of mutations in a particular gene as detected by a selective mutation assay could be affected by the structural properties of the target protein. To investigate this, we have analysed N-methyl-N-nitrosourea (MNU)-induced mutations in two restriction recognition sequences of a target gene for mutation analysis and compared these data with what previously observed in a phenotypic...
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1974
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1974.19